What is membranous nephropathy?

5 December 2023

It is a pathology in which the kidneys’ glomeruli, responsible for filtering waste substances and liquids from the blood, widen and proteins reach the urine, causing kidney damage.

Membranous nephropathy can develop slowly as a reaction of the immune system or due to the presence of some viral infections, such as hepatitis B and C; autoimmune diseases, such as lupus erythematosus; cancer, especially colon and lung cancer; or some medications such as non-steroidal anti-inflammatory drugs. However, it can also occur along with other kidney diseases, such as diabetic nephropathy and glomerulonephritis.

This condition can occur at any age, but it usually appears after the age of 40.

Signs and symptoms Membranous nephropathy

Some people may not have symptoms until the disease is in an advanced stage, but they usually experience:

Increase in body weight due to excess fluid.
High cholesterol.
Hematuria.
Creatinine in the blood.
Decreased albumin.
Edema in any part of the body, especially legs and ankles.
Fatigue.
Increased protein in the urine.
Lack of appetite.
Foam in the urine.

Membranous nephropathy risks and complications:

High cholesterol.
Clot formation, mainly in the legs and lungs.
Chronic kidney disease.
Recurrent infections due to loss of antibodies.
Acute kidney failure.
High blood pressure.
Nephrotic syndrome.

Diagnosis and treatment Membranous nephropathy

Once your doctor analyzes your symptoms and clinical history, they will perform a physical examination and request the following tests to make an accurate diagnosis:

Analysis of glomerular filtration rate.
Antibody analysis.
Kidney biopsy.
Ultrasound.
Blood and urine tests.
Cryoglobulin test.
MRI.

Treatment will depend on the progression of the disease and will seek to improve symptoms, as well as prevent the disease from evolving through a low sodium and low protein diet, and the intake of anticoagulants, corticosteroids, diuretics, and statins.

In Saludora Medical Center Internal Medicine Department, we provide you with health care services with the highest quality and safety, from prevention, diagnosis, timely treatment, and follow-up of infectious, respiratory, endocrinological, dermatological, rheumatic, nephrological, gastrointestinal, and hematological conditions, both chronic-degenerative and acute, through a comprehensive and multidisciplinary model.

Related centers and departments Membranous nephropathy

Internal Medicine
Radiology and Molecular Imaging
Clinical Laboratory
Cancer Center

Fuentes:

kidneyfund.org
revistanefrologia.com
nefrologiaaldia.org
medlineplus.gov
cun.es
topdoctors.es
mayoclinic.org
msdmanuals.com
medigraphic.com
Pazarín-Villaseñor L, Villanueva-Pérez A, Ortiz-López CR. Nefropatía membranosa como causa de síndrome nefrótico posterior a trasplante renal. Rev Mex Traspl. 2017;6(2):75-80.

How can we help you?

The dissemination of the content of this material is for informational purposes only and does not replace, under any circumstance or condition, a consultation with a specialist doctor, for which the Saludora Medical Center is not responsible for the different use that may be given to it. If you require more information related to the subject, we suggest you contact the specialist doctor you trust directly.

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Comparison of COVID-19 vaccines

Pfizer-
BioNTech

Pfizer-BioNTech

What is its effectiveness and what does it refer to?

Vaccine type: mRNA
Effectiveness: 95% after the second dose in the prevention of symptomatic COVID-19.

No Does not contain egg, latex, or preservatives.

How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).

Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 16 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine such as polyethylene glycol (PEG) or polysorbate.

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, malaise, and swollen lymph nodes.

How long will it take for me to be protected and what does it protect me from?
After 14 days of having the complete scheme (after the administration of the 2nd dose), the protection period is still under study. It protects us from serious COVID-19 or requiring hospitalization.

Moderna

What is its effectiveness and what does it refer to?

Vaccine type: mRNA
Effectiveness: 94.5% after the second dose in the prevention of symptomatic COVID-19.

Does not contain egg, latex, or preservatives.

How many doses are needed?
Two doses are needed, at least 28 days apart (or up to six weeks apart, if necessary).

Who should or shouldn’t get the vaccine?
People who should receive the vaccine are those over 18 years old.
People who should not receive the vaccine are those who have a history of anaphylactic shock (severe allergy) or who are allergic to any component of this vaccine.

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, muscle pain, chills, joint pain, fever, nausea, and swollen lymph nodes in the arm in which you received the injection.

Janssen/
Johnson
& Johnson

Janssen/ Johnson & Johnson

What is its effectiveness and what does it refer to?

Vector-based vaccine.
Effectiveness: 72.0% in the prevention of symptomatic COVID-19.
85% in the prevention of severe COVID-19.

Does not contain egg, latex, or preservatives./strong>

How many doses are needed?
Only one dose in needed.

What are the possible side effects of the vaccine?
Pain where the injection was given, headache, fatigue, muscle pain, chills, fever, and nausea.

How long will it take for me to be protected and what does it protect me from?
After 28 days of having the complete scheme (the last dose applied), the protection period is still under study. It protects us from 85% serious COVID-19 or requiring hospitalization.

AstraZeneca
and
Oxford
University

AstraZeneca and Oxford University

What is its effectiveness and what does it refer to?

Adenovirus vector-based vaccine.
Effectiveness: 82% after the second dose in the prevention of symptomatic COVID-19.

How many doses are needed?
Two doses are needed, at least 56 days apart (or up to 84 days apart, if necessary).

What are the possible side effects of the vaccine?
Pain where the injection was given, fatigue, headache, myalgia, arthralgia, and fever, which were mild to moderate in intensity and disappeared within 48 hours of vaccination.

Sputnik V

What is its effectiveness and what does it refer to?

Adenovirus vector-based vaccine.
Effectiveness: 92% after the second dose in the prevention of symptomatic COVID-19.

How many doses are needed?
Two doses are needed, at least 21 days apart (or up to six weeks apart, if necessary).

What is membranous nephropathy?

Signs and symptoms Membranous nephropathy

Diagnosis and treatment Membranous nephropathy

Related centers and departments Membranous nephropathy

Fuentes:

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Specialist in Membranous nephropathy